From Chapter 3:
The fumes of dried coltsfoot leaves were used as a remedy in cases of difficulty of breathing, both in ancient Roman times and in Tudor England. Lyte, in his translation, 1578, of Dodoens' "Historie of Plants," says of coltsfoot: "The parfume of the dryed leaves layde upon quicke coles, taken into the mouth through the pipe of a funnell, or tunnell, helpeth suche as are troubled with the shortnesse of winde, and fetche their breath thicke or often, and do [sic] breake without daunger the impostems of the breast." The leaves of coltsfoot and of other plants have often been used as a substitute for tobacco in modern days. A correspondent of Notes and Queries, in 1897, said that when he was a boy he knew an old Calvinist minister, who used to smoke a dried mixture of the leaves of horehound, yarrow and "foal's foot" intermingled with a small quantity of tobacco. He said it was a very good substitute for the genuine article. Similar mixtures, or the leaves of coltsfoot alone, have often been smoked in bygone days by folk who could not afford to smoke tobacco only.

From Chapter 5:
Among the many medicinal virtues attributed to tobacco was its supposed value as a preservative from contagion at times of plague. Hearne, the antiquary, writing early in 1721, said that he had been told that in the Great Plague of London of 1665 none of those who kept tobacconists' shops suffered from it, and this belief no doubt enhanced the medical reputation of the weed. I have also seen it stated that during the cholera epidemics of 1831, 1849, and 1866 not one London tobacconist died from that disease; but good authority for the statement seems to be lacking. Hutton, in his "History of Derby," says that when that town was visited by the plague in 1665, that at the "Headless-cross ... the market-people, having their mouths primed with tobacco as a preservative, brought their provisions.... It was observed, that this cruel affliction never attempted the premises of a tobacconist, a tanner or a shoemaker." Whatever ground there may have been for the belief in the prophylactic effect of smoking, there can be no doubt that in the seventeenth century it was firmly held. Howell in one of his "Familiar Letters" dated January 1, 1646, says that the smoke of tobacco is "one of the wholesomest sents that is against all contagious airs, for it overmasters all other smells, as King James they say found true, when being once a hunting, a showr of rain drave him into a Pigsty for shelter, wher he caus'd a pipe full to Be taken of purpose." But here Mr. Howell is certainly drawing the long-bow. One cannot imagine the author of the "Counterblaste" countenancing the use of tobacco under any circumstances.