From Chapter 1:
At the fifteenth-century Manor-House at South Wraxall, Wiltshire, the "Raleigh Room" is shown, and visitors are told that according to local tradition it was in this room that Sir Walter smoked his first pipe, when visiting his friend, the owner of the mansion, Sir Henry Long.

From Chapter 6:
Other well-known men of the late seventeenth century were "tobacconists" in the old sense of the word. Sir Isaac Newton is said to have smoked immoderately; and a familiar anecdote represents him as using for the purposes of a tobacco-stopper, in a fit of absent-mindedness, the little finger of a lady sitting beside him, whom he admired, but the truth of this legend is open to doubt. Thomas Hobbes, who lived to be ninety (1588-1679), was accustomed to dine at 11 o'clock, after which he smoked a pipe and then lay down and took a nap of about half an hour. No doubt he would have attributed the length of his days to the regularity of his habits. Izaak Walton, who also lived to be ninety, as the lover of the placid and contemplative life deserved to do, loved his pipe, though he seldom mentions smoking in the "Compleat Angler." Sir Samuel Garth, poet and physician, once known to fame as the author of "The Dispensary," was another pipe-lover, as is shown by his verses quoted at the head of this chapter. Dudley, the fourth Lord North, began to smoke in 1657, and, says Dr. Jessopp, "the habit grew upon him, the frequent entries for pipes and tobacco showing that he became more and more addicted to this indulgence. Probably it afforded him some solace in the dreadful malady from which he suffered so long."