From Chapter 3:
Another tract which may be classed with Venner's "Treatise" was the "Nepenthes or the Vertues of tobacco," by Dr. William Barclay, which was published at Edinburgh in 1614. This is sometimes referred to and quoted, as by Fairholt, as if it were a whole-hearted defence of tobacco-taking. But Barclay enlarges mainly on the medicinal virtues of the herb. "If Tabacco," he says, "were used physically and with discretion there were no medicament in the worlde comparable to it"; and again: "In Tabacco there is nothing which is not medicine, the root, the stalke, the leaves, the seeds, the smoake, the ashes." The doctor gives sundry directions for administering tobacco—"to be used in infusion, in decoction, in substance, in smoke, in salt." But Barclay clearly does not sympathize with its indiscriminate use for pleasure. "As concerning the smoke," he says, "it may be taken more frequently, and for the said effects, but always fasting, and with emptie stomack, not as the English abusers do, which make a smoke-boxe of their skull, more fit to be carried under his arme that selleth at Paris dunoir a noircir to blacke mens shooes then to carie the braine of him that can not walke, can not ryde except the Tabacco Pype be in his mouth." He goes on to say that he was once in company with an English merchant in Normandy—"betweene Rowen and New-haven"—who was a merry fellow, but was constantly wanting a coal to kindle his tobacco. "The Frenchman wondered and I laughed at his intemperancie."

From Chapter 8:
Parr is said on one occasion to have called for a pipe after taking a meal at a coaching-inn called the "Bush" at Bristol, when the waiter told him that smoking was not allowed at the Bush. Parr persisted, but the authorities at the inn were firm in their refusal to allow anything so vulgar as smoking on their premises, whereupon Parr is said to have exclaimed: "Why, man, I've smoked in the dining-room of every nobleman in England. The Duchess of Devonshire said I could smoke in every room in her house but her dressing-room, and here, in this dirty public-house of Bristol you forbid smoking! Amazing! Bring me my bill." The learned doctor exaggerated no doubt as regards the facilities given him for smoking; for it was his overbearing way not to ask for leave to smoke, but to smoke wherever he went, whether invited to do so or not; but the story shows the prejudice against smoking which was found in many places as a result of the attitude of the fashionable world towards tobacco.