From Chapter 3:
Penalties for "offences" of this fanciful kind were not common in England; but in Puritan New England they were abundant. In the early days of the American Colonies the use of the "creature called Tobacko" was by no means encouraged. In Connecticut a man was permitted by the law to smoke once if he went on a journey of ten miles, but not more than once a day and by no means in another man's house. It could hardly have been difficult to evade so absurd a regulation as this.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."